Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease

Effect of CD40 and sCD40L on renal function and survival in patients with renal artery stenosis.

Activation of the CD40 receptor on the proximal tubular epithelium of the kidney results in fibrosis and inflammation in experimental models of kidney injury. Soluble CD40 ligand is released by activated platelets. The role of CD40-soluble CD40 ligand in patients with ischemic renal disease is unknown. Plasma levels of CD40 and soluble CD40 ligand were measured by enzyme-linked immunosorbent as...

HEARING LOSS IN CHRONIC RENAL FAILURE AND CHANGES WITH KIDNEY TRANSPLANTATION

Loss of hearing is a known problem in patients with chronic renal failure, occurring in 40-XO% of cases and being most often of the high frequency sensorineural type. We performed a study on 50 patients with this disease, including 20 who had undergone a successful kidney transplantation. Our results show an 80% incidence of hearing loss in these patients and a chance of improvement in at l...

Large kidneys predict poor renal outcome in subjects with diabetes and chronic kidney disease

BACKGROUND Renal hypertrophy occurs early in diabetic nephropathy, its later value is unknown. Do large kidneys still predict poor outcome in patients with diabetes and Chronic Kidney Disease (CKD)? METHODS Seventy-five patients with diabetes and CKD according to a Glomerular Filtration Rate (GFR, by 51Cr-EDTA clearance) below 60 mL/min/1.73 m2 or an Albumin Excretion Rate above 30 mg/24 H, h...

the impact of human recombinant erythropoietin on renal function in patients with chronic kidney disease

Circulating TNF receptors predict cardiovascular disease in patients with chronic kidney disease

Cardiovascular disease (CVD) is the main public health problem in patients with chronic kidney disease (CKD); however, there is no established biomarker for predicting CVD morbidity and mortality in CKD. The aim of this study was to evaluate the role of circulating tumor necrosis factor receptors (cTNFRs) in predicting CVD risk in CKD patients.We prospectively recruited 984 patients with CKD fr...